Y Combinator Startup Podcast

"The CEO Must Be the Chief AI Officer"

Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for bui...

2026-06-10

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How to Build an AI-Native Services Company

Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI ...

2026-06-04

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How To Build Superintelligence Inside Your Company

Building superintelligence inside a company isn't about adding AI as a feature. It's about making it the operating system the whole organization runs on. In this episode of the Lightcone, we s...

2026-05-27

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How The Best Companies Defend Against Mediocrity And Rot

In this episode of the Main Function Garry sits down with Eric Ries, author of "The Lean Startup", about his new book, "Incorruptible: Why Good Companies Go Bad And How Great Companies ...

2026-05-26

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Paul Graham: Should you move to Silicon Valley?

Paul Graham is a co-founder of Y Combinator. He's funded and mentored companies like Dropbox, Airbnb, DoorDash, and thousands of others through YC, and is one of the most influential voices in the sta...

2026-05-14

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Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers

We're entering a new era of software where a single person, working with AI agents, can build products that previously required entire teams.In this episode of Lightcone, the hosts break down the rise...

2026-05-08

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Beyond Bigger Models: Recursion As The Next Scaling Law In AI

A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Fra...

2026-05-01

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How to Build the Future: Demis Hassabis

Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. H...

2026-04-29

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The $9B Startup That Wants to Create a Billion New Developers

Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series ...

2026-04-26

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The Playbook For Building An AI Native Company

AI isn't just making teams more productive. It's changing how companies should be built. In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native co...

2026-04-25

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Stripe Head of Design Katie Dill Breaks Down Their New Website

Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech gia...

2026-04-22

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The GPT Moment for Robotics Is Here

Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics. The company's cross-embodiment approach ...

2026-04-16

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This Startup Wants To Catch Cancer Before It Spreads

1 in 11 babies born in America this year will be screened by a genetic test that didn't exist a decade ago.Biotech startup BillionToOne turned a simple but radical idea—detecting rare fragments of...

2026-04-06

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This Startup Secretly Detects Fraud For Fortune 500s

In this episode of Founder Firesides, YC Managing Partner Jared Friedman talks to Karine Mellata, co-founder of Variance (W23), who is coming out of stealth and announcing their $21 million Series A. ...

2026-04-01

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How François Chollet Is Building A New Path To AGI

François Chollet has spent years asking a different question than most of the AI world. Instead of scaling what already works, he’s trying to understand what intelligence actually is—and how to build ...

2026-03-27

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Inside The Startup Reinventing America’s Trillion Dollar Chemical Industry

Solugen is reinventing the trillion-dollar chemical manufacturing industry by combining biology and chemistry in a new way. In this episode of Hard Tech, YC's Jared Friedman visits co-founders Gaurab ...

2026-03-20

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Building A Global AI Startup From India

In this episode of The Lightcone, we talk with Mukund and Madhav Jha, the founders of Emergent - an AI platform that lets anyone build and ship production-ready software. In just eight months, users h...

2026-03-16

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The Future Of Brain-Computer Interfaces with Science's Max Hodak

YC alum Max Hodak is the co-founder of Neuralink and founder of Science, a company building brain-computer interfaces that can restore sight.Science has developed a tiny retinal implant that stimulate...

2026-03-09

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How To Avoid AI Design Slop

As no-code design tools become more common, so do the pitfalls. You know what they look like - the purple gradients, annoying hover effects, sections that fade as you scroll. So how do you avoid a sit...

2026-03-07

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The Fastest Path To Super Intelligence

Poetiq is a new startup founded by former DeepMind researchers that recently achieved a major jump on the ARC-AGI and Humanity's Last Exam benchmark by layering a recursive self-improvement system...

2026-02-27

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Y Combinator Startup Podcast

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