The a16z Show

Crypto Fund 5: We Raised $2.2B. Here’s Why.

Robert Hackett speaks with the general partners at a16z crypto about the launch of their fifth crypto fund and the current state of the industry. They reflect on how crypto has evolved from an ideolog...

2026-05-07

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The New Space Race: NASA, Artemis, and the Race to the Moon

Morgan Brennan speaks with NASA Administrator Jared Isaacman about the next phase of American space exploration and the urgency behind returning to the moon. They discuss the Artemis program, the chal...

2026-05-06

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Building Blackstone, Backing Costco, with Tony James

David Haber speaks with Tony James about building enduring firms across multiple eras of finance. From joining DLJ when it was a subscale firm to helping grow Blackstone into one of the largest asset ...

2026-05-05

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Sarah Rogers: Free Speech, AI Diplomacy, and What America Owes Its Allies

Katherine Boyle speaks with Sarah Rogers, Under Secretary for Public Diplomacy, about the intersection of AI, free speech, and global information systems. They discuss how major technological shifts, ...

2026-05-04

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Balaji and Taylor Lorenz on AI and Media

Theo Jaffee speaks with Balaji Srinivasan and Taylor Lorenz about how AI is reshaping media, trust, and online communication. Building on prior public disagreements between the two, the conversation r...

2026-05-01

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Workday’s Last Workday? AI and the Future of Enterprise Software

Elena Burger speaks with Joe Schmidt, partner on the enterprise team at a16z, about the future of enterprise software in the age of AI. Using Workday as a case study, they discuss why many of today’s ...

2026-04-30

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The Shift in Global Drug Development

Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise to the top of global clinical trial output. They discuss the regulatory reforms that accelerated China’s progress, the su...

2026-04-29

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John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require...

2026-04-28

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Ben Horowitz on Venture Capital and AI

Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven business into a scalable system for backing new techn...

2026-04-27

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AI Inside the Enterprise

Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and...

2026-04-24

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Martin Shkreli on AI, Pharma, and What Actually Matters

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk th...

2026-04-23

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Balaji Srinivasan: Prove Correct, Not Just Go Direct

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how informa...

2026-04-22

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Marc Andreessen: Monitoring the Situation and the Future of Media

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss ...

2026-04-21

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Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both hu...

2026-04-21

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Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of netw...

2026-04-19

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The System Behind Self-Driving: Waymo’s Dmitri Dolgov

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, an...

2026-04-17

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Technology, Culture, and the Next AI Interface with signüll

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge ...

2026-04-16

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Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based ...

2026-04-15

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Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of s...

2026-04-14

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Building Agents at Home: Parenting, Work, and Benevolent Neglect

Katherine Boyle and Sarah Wang speak with Jesse Genet, a startup founder and family builder, about building 11 AI agents while homeschooling four young children. Jesse runs agents across roles ranging...

2026-04-13

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The a16z Show

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