The a16z Show

AI Inside the Enterprise

Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and...

2026-04-24

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Martin Shkreli on AI, Pharma, and What Actually Matters

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk th...

2026-04-23

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Balaji Srinivasan: Prove Correct, Not Just Go Direct

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how informa...

2026-04-22

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Marc Andreessen: Monitoring the Situation and the Future of Media

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss ...

2026-04-21

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Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both hu...

2026-04-21

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Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of netw...

2026-04-19

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The System Behind Self-Driving: Waymo’s Dmitri Dolgov

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, an...

2026-04-17

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Technology, Culture, and the Next AI Interface with signüll

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge ...

2026-04-16

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Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based ...

2026-04-15

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Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of s...

2026-04-14

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Building Agents at Home: Parenting, Work, and Benevolent Neglect

Katherine Boyle and Sarah Wang speak with Jesse Genet, a startup founder and family builder, about building 11 AI agents while homeschooling four young children. Jesse runs agents across roles ranging...

2026-04-13

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What Running Windows at Microsoft Taught Steven Sinofsky About Apple

Theo Jaffee speaks with Steven Sinofsky, board partner at a16z and former president of the Windows division at Microsoft, about Apple's 50th anniversary, the cultural differences that separated Apple ...

2026-04-10

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Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate

Eddy Lazzarin speaks with Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic, about whether AI progress can or should be steered, the risks of concentrated power, ...

2026-04-09

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The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie

Erik Torenberg, Steve Sinofsky, and Martin Casado speak to Aaron Levie, CEO at Box, about what happens to enterprise software when agents become the primary users. They discuss why coding agents succe...

2026-04-08

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Balaji on Why AI Raises the Cost of Verification

a16z general partner Erik Torenberg speaks with Balaji Srinivasan, angel investor and entrepreneur, about why AI simultaneously reduces the cost of creation and increases the cost of verification, and...

2026-04-07

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Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why coding agents feel like slot machines, and what hap...

2026-04-06

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Marc Andreessen on AI Winters and Agent Breakthroughs

This episode originally aired on the Latent Space Podcast. swyx and Alessio Fanelli speak with Marc Andreessen about the arc of AI from its origins in 1943 to today's breakthroughs in reasoning, codin...

2026-04-04

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Alex Blania on Proof of Human and Building World's Identity Network

a16z's Ben Horowitz and Erik Torenberg speak with Alex Blania, cofounder and CEO of Tools for Humanity, World, and cofounder of Merge Labs. World is building the largest real human network, a proof-of...

2026-04-02

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What Happens When a Public Company Goes All In on AI

David Haber speaks with Owen Jennings, executive officer and business lead at Block, about how the company rebuilt itself around AI agents, small squads, and internal tools like Goose and Builder Bot ...

2026-04-01

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How Radiant and Heron Are Rethinking Power Generation and Delivery

a16z general partners Erin Price-Wright and Erik Torenberg speak with Doug Bernauer, founder and CEO of Radiant, and Drew Baglino, founder and CEO of Heron, about rebuilding American energy infrastruc...

2026-03-31

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