The a16z Show

OpenAI: When AI Agents Use Computers Faster Than You

AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstei...

2026-10-26

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The New Startup Playbook | Box CEO Aaron Levie

Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before...

2026-10-25

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What It Takes to Win as a Founder | Ben Horowitz

What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, maki...

2026-10-24

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Amazon CEO Andy Jassy on the $220 Billion AI Buildout

Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help ...

2026-10-23

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The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon

a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to ex...

2026-10-23

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The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham

AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably underst...

2026-10-21

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What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal

More than 300 million people use ChatGPT for health and wellness questions each week. OpenAI’s Karan Singhal thinks that’s only the beginning: the longer-term goal is AI that can help people navigate ...

2026-10-20

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What Happens When Al Agents Can Spend Your Money?

Why hasn't AI transformed everyday work as quickly as coding? Town CEO Jean-Denis Greze argues the bottleneck isn't intelligence, but making AI useful to people who don't have the time or technical sk...

2026-10-19

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Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential i...

2026-10-18

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Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

Why is booking a doctor's appointment still so difficult, and can AI finally change that? Zocdoc CEO Oliver Kharraz argues that the real problem isn't finding doctors, but connecting patients to accur...

2026-10-17

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AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

a16z General Partner Martin Casado sits down with Grepr CEO Jad Naous to ask what comes after AI learns to write code: can it also debug and operate the systems that code creates? Jad shares how AI h...

2026-10-16

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When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

a16z General Partner Alex Rampell sits down with VGS Executive Board Member, Terry Angelos, to unpack what happens to payments when AI agents go from recommending what to buy to actually making the pu...

2026-10-15

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Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

a16z Partner Lisha Li sits down with AI researcher and Trillium founder Nathan Lambert to ask how durable the gap really is between frontier AI labs and open models. Nathan argues that OpenAI and Ant...

2026-10-14

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Can AI Break Cryptography? What the Experts Actually Think

Could AI break the cryptography protecting everything from crypto wallets and banking to private messages? Recent advances in AI-driven mathematical research have sparked new warnings about the securi...

2026-10-13

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The Race to Recursive Self-Improving AI

a16z General Partner Martin Casado sits down with MakerMaker.AI co-founders Dhaval Adjodah and Owen He to unpack recursive self-improvement, or RSI, and separate the increasingly popular term from wha...

2026-10-12

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Nick Bostrom: How Should We Navigate Superintelligence?

Nick Bostrom joins Theo Jaffee and Sofia Puccini on MTS to revisit the ideas about superintelligence and existential risk that he helped bring into the mainstream, now that increasingly capable AI sys...

2026-10-11

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What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

a16z co-founder and General Partner Ben Horowitz joins James Norman on the inaugural episode of Vintage x Vintage for a conversation spanning entrepreneurship, investing, hip-hop, and what changes whe...

2026-10-10

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Chips, Memory, and Power | Pat Gelsinger

a16z's Raghu Raghuram and Guido Appenzeller sit down with Playground Global General Partner and former Intel CEO Pat Gelsinger to discuss the next wave of semiconductor innovation and the physical con...

2026-10-09

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Building the Cloud for an Agentic World | AWS CEO Matt Garman

a16z’s Raghu Raghuram sits down with AWS CEO Matt Garman to discuss how AI is reshaping the cloud, from the needs of AI-native startups to infrastructure increasingly designed for agents. Matt explai...

2026-10-08

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How Valon Rebuilt a $13 Trillion Industry From Scratch

a16z General Partner Angela Strange sits down with Valon’s Andrew Wang and Linda Du to unpack what it takes to rebuild the infrastructure underneath a $13 trillion mortgage market that still relies he...

2026-10-07

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The a16z Show

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