The a16z Show

What It Takes to Build a Startup | Andrew Chen & Matt Perault

a16z’s Matt Perault sits down with General Partner and Speedrun lead Andrew Chen on the a16z AI Policy Brief to explore what “Little Tech” actually looks like at the earliest stages, and why the reali...

2026-09-11

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How AI Is Rewriting the Power Law of Venture Capital

a16z’s Jen Kha and David George sit down with Accolade Partners’ Aram Verdiyan to discuss how AI is changing the power law of technology investing, why the largest companies can compound advantages in...

2026-09-10

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Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

a16z’s Erik Torenberg, Ben Horowitz, and Jennifer Li sit down with Vals founder and CEO Rayan Krishnan to discuss one of AI’s increasingly difficult problems: how do you actually measure whether a mod...

2026-09-09

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OpenAI Researchers on the Future of Mathematical Reasoning

a16z Infra Partner Lisha Li sits down with OpenAI mathematicians Mehtaab Sawhney and Mark Sellke to discuss how quickly AI’s mathematical capabilities are advancing, what recent results reveal about m...

2026-09-08

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Can Open Source Keep AI Power From Concentrating?

MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI power from concentrating in the...

2026-09-07

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Your AI Doctor Is Coming | Julie Yoo

a16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades of slow technology adoption m...

2026-09-06

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Aaron Levie on Why Open AI Wins

Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, and explain why he believes mor...

2026-09-05

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Fei Fei Li: The Race to Build World Models For AI

World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reveals about the pursuit of spati...

2026-09-04

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The $100B Niches Hiding Inside Payments

Erik Torenberg is joined by a16z General Partner Alex Rampell and Affirm Co-Founder and CEO Max Levchin for a conversation on 25 years of fintech, from the early days of digital payments to the origin...

2026-09-03

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Inside Moderna’s Personalized Cancer Vaccine

a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment...

2026-09-02

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Daniel Litt: The Mathematician's Guide to AI

a16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI's rapid progress in mathematics, what today's frontier models can actually do,...

2026-09-01

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Gavin Baker: Why AI Demand Is Outrunning Compute Supply

a16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outcome doesn't necessarily have to...

2026-08-31

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Why a16z Launched the Machine Age Fund | Jen Kha

a16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z's Machine Age Fund and the investment thesis behind rebuilding the physical inf...

2026-08-30

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Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

Ryan Greenblatt, Chief Scientist at Redwood Research, joins MTS host Theo Jaffee to unpack a new independent investigation into the OpenAI Hugging Face hacking incident and what it reveals about how l...

2026-08-29

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The Infrastructure Behind the Machine Age

Ben Horowitz, Martin Casado, Raghu Raghuram, and Erik Torenberg discuss the launch of a16z's new Machine Age Fund and the infrastructure buildout behind AI, from chips, memory, and networking to power...

2026-08-28

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Inside Cursor: The Anatomy of a Generational Startup

a16z General Partners Martin Casado, Sarah Wang, and Matt Bornstein unpack the story of Cursor: how a small, product-obsessed team entered one of the most competitive markets in technology, took on in...

2026-08-27

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The State of AI: Macro, Apps, and Consumer

Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer, and consumer AI in particular, may be entering a n...

2026-08-26

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The New Economics of AI | Martin Casado & Steven Sinofsky

a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and mathematics tell us about where the technology is head...

2026-08-25

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Why Medical AI Needs a Referee | Protege's Engy Ziedan

Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why scoring well on a benchmark does...

2026-08-24

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Martin Casado on Where the Value Is Going in AI

Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamentally different from previous waves, and whether the ...

2026-08-22

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The a16z Show

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